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Dp(5Gtf2i-Gtf2ird1)1Lro Cytogenetic Marker Detail
Summary
  • Symbol
    Dp(5Gtf2i-Gtf2ird1)1Lro
  • Name
    duplication, Chr 5, L Osborne 1
  • Synonyms
    Dp(5Gtf2i-Gtf2ird)1Lro
  • Feature Type
    chromosomal duplication
  • IDs
    MGI:5490971
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 5, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for this duplication exhibit increased ultrasonic vocalization during maternal-separation period.
References
more
  • Summaries
    All 6
    Phenotypes 5
  • Earliest
    J:222543 Proulx E, et al., Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. J Neurodev Disord. 2010 Jun;2(2):99-108
  • Latest
    J:343071 Lopez-Tobon A, et al., GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders. Sci Adv. 2023 Dec;9(48):eadh2726
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory