Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Prg4tm1(GFP/cre/ERT2)Abl
Name:	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 1, Andrew Lassar
MGI ID:	MGI:5490969
Synonyms:	Prg4GFPCreERt2
Gene:	Prg4  Location: Chr1:150325163-150341916 bp, - strand  Genetic Position: Chr1, 63.84 cM, cytoband G
Alliance:	Prg4tm1(GFP/cre/ERT2)Abl page

Germline Transmission:	Earliest citation of germline transmission: J:197163
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Prg4tm1(GFP/cre/ERT2)Abl expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Prg4 (MGI:1891344)   Mutation details: A targeting vector containing a GFP/cre/ERT2 (green fluorescent protein, cre recombinase and estrogen receptor 1 tamoxifen binding domain fusion gene and an FRT flanked PGK-NEO selection cassette), was inserted into the translation initiation codon of exon 2 of the Prg4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein). The resulting chimeric animals were crossed to FLP recombinase expressing mice (ACT-FLPe) mice (on an unknown genetic background) to remove the Frt flanked PGK-neo selection cassette. (J:197163)

Activity:	Tissue activity of this recombinase allele
Driver:	Prg4 (mouse) Summary of all recombinase alleles driven by Prg4. Comparative matrix view of recombinase activities Alliance mouse Prg4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prg4 Mutation:	71 strains or lines available

Original:	J:197163 Lassar A, Generation of cre knockin allele of Prg4. MGI Direct Data Submission. 2013;
All:	11 reference(s)