Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stra6tm1Nbg
Name:	stimulated by retinoic acid gene 6; targeted mutation 1, Norbert B Ghyselinck
MGI ID:	MGI:5490784
Synonyms:	Stra6L-, Stra6tm2.2Nbg
Gene:	Stra6  Location: Chr9:57971071-58061279 bp, + strand  Genetic Position: Chr9, 31.63 cM, cytoband C
Alliance:	Stra6tm1Nbg page

Germline Transmission:	Earliest citation of germline transmission: J:196841
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 5 through 7. Western blot analysis confirmed the absence of protein expression in E9.5 embryos and the retinal pigment epithelium. This allele was generated from Stra6tm2.1. (J:196841, J:203449)

Generation of the Stra6tm2.1Nbg and Stra6tm1Nbg alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stra6 Mutation:	48 strains or lines available

Original:	J:196841 Ruiz A, et al., Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012;53(6):3027-39
All:	4 reference(s)