Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Egr3tm1.1(cre)Wgt
Name:	early growth response 3; targeted mutation 1.1, Warren G Tourtellotte
MGI ID:	MGI:5489890
Synonyms:	Egr3Cre
Gene:	Egr3  Location: Chr14:70314766-70320062 bp, + strand  Genetic Position: Chr14, 36.2 cM, cytoband D1
Alliance:	Egr3tm1.1(cre)Wgt page

Germline Transmission:	Earliest citation of germline transmission: J:196371
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Egr3tm1.1(cre)Wgt expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Egr3 (MGI:1306780)   Mutation details: By homologous recombination, a targeting construct replaced the endogenous exon 1, intron, and exon 2 of Egr3 with a cassette encoding nuclear-localized cre recombinase with and a PGK-neo selection marker flanked with forward-oriented Frt sites. The neo was excised from the germline by mating mice to CAG-FLPe mice. (J:196371)

Activity:	Tissue activity of this recombinase allele
Driver:	Egr3 (mouse) Summary of all recombinase alleles driven by Egr3. Alliance mouse Egr3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr3 Mutation:	15 strains or lines available

Original:	J:196371 Quach DH, et al., A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci. 2013 Mar 6;33(10):4570-83
All:	2 reference(s)