Gjb6tm1Mcsa
Targeted Allele Detail
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| Symbol: |
Gjb6tm1Mcsa |
| Name: |
gap junction protein, beta 6; targeted mutation 1, Martine Cohen-Salmon |
| MGI ID: |
MGI:5486676 |
| Synonyms: |
Cx30fl |
| Gene: |
Gjb6 Location: Chr14:57360760-57371068 bp, - strand Genetic Position: Chr14, 30.1 cM
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| Alliance: |
Gjb6tm1Mcsa page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:193913
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 3 and a floxed pgk-hygromycin cassette was inserted downstream of exon 3 via homologous recombination. Quantitative PCR and immunoblot analysis indicate a decrease in mRNA and protein expression in the inner ear of homozygous mice. Expression of Gjb2 mRNA and protein are also reduced in the inner ear of homozygous mice.
(J:193913)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gjb6 Mutation: |
18 strains or lines available
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| Original: |
J:193913 Boulay AC, et al., Hearing is normal without connexin30. J Neurosci. 2013 Jan 9;33(2):430-4 |
| All: |
3 reference(s) |
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Analysis Tools
