Tg(Cyp1a1-creA)1Dwi
Transgene Detail
|
|
| Symbol: |
Tg(Cyp1a1-creA)1Dwi |
| Name: |
transgene insertion 1, Douglas J Winton |
| MGI ID: |
MGI:5486347 |
| Synonyms: |
Cyp1a1-H2B-creA |
| Transgene: |
Tg(Cyp1a1-creA)1Dwi Location: unknown
|
| Alliance: |
Tg(Cyp1a1-creA)1Dwi page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
| Inducer: |
|
beta-naphthoflavone |
| Mutation: |
|
Insertion
|
| |
|
Tg(Cyp1a1-creA)1Dwi expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| rat |
Cyp1a1 (24296) |
|
|
|
| |
|
Mutation details: The creA fragment of the cre coding sequence (codons 19-59) was fused by flexible F2 linkers to other protein motifs (human H2B and the FKBP dimerizing domain) and a polyadenylation sequence is added. This cassette was cloned into a vector such that it was under transcriptional control of a 12 kb rat Cyp1a1 promoter element. The purified construct was used for pronuclear injection to generate transgenic mice. Beta-naphthoflavone is used to induce the Cyp1a1 promoter so that cre A is produced. These mice are bred with animals expressing the creB fragment of the cre CDS. When dimerization is induced by treatment with AP20187.
(J:194841)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Cyp1a1
(rat)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:194841 Buczacki SJ, et al., Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013 Mar 7;495(7439):65-9 |
| All: |
1 reference(s) |
|
Analysis Tools
