Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Wwtr1tm1Hmc Name: WW domain containing transcription regulator 1; targeted mutation 1, Helen McNeill MGI ID: MGI:5486299 Synonyms: Tazflox Gene: Wwtr1  Location: Chr3:57363070-57483331 bp, - strand  Genetic Position: Chr3, 27.74 cM Alliance: Wwtr1tm1Hmc page

Nephrogenesis abnormalities in Wwtr1tm1Hmc/Wwtr1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+, Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ and double mutant mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:195266
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 1 and a loxP site and FRT-flanked neo cassette were inserted in intron 2 via homologous recombination. (J:195266)

Generation of the Wwtr1tm1Hmc allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wwtr1 Mutation:	23 strains or lines available

Original:	J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
All:	43 reference(s)