Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Yap1tm1Hmc Name: yes-associated protein 1; targeted mutation 1, Helen McNeill MGI ID: MGI:5486298 Synonyms: Yapflox Gene: Yap1  Location: Chr9:7932000-8004597 bp, - strand  Genetic Position: Chr9, 2.46 cM Alliance: Yap1tm1Hmc page

Abnormal kidney development in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice Show the 7 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:195266
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT flanked splice acceptor-IRES-betageo cassette and loxP site were inserted in intron 1 and a loxP site was inserted in intron 2 via homologous recombination. (J:195266)

Generation of the Yap1tm1Hmc allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yap1 Mutation:	37 strains or lines available

Original:	J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
All:	45 reference(s)