Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Fahem1Mvw
Name:	fumarylacetoacetate hydrolase; endonuclease-mediated mutation 1, Michael Wiles
MGI ID:	MGI:5485380
Synonyms:	Fahdeltaexon9
Gene:	Fah  Location: Chr7:84234367-84255150 bp, - strand  Genetic Position: Chr7, 48.36 cM
Alliance:	Fahem1Mvw page

Strain of Origin:

NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Zinc finger nuclease (ZFN) editing induced a deletion of 172 bp in exon 9 of the Fah gene. The deletion results in a premature stop codon. (J:262087)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fah Mutation:	36 strains or lines available

Original:	J:262087 Winer BY, et al., Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection. Virology. 2017 Feb;502:63-72
All:	2 reference(s)