Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ghrltm1Suss
Name:	ghrelin; targeted mutation 1, Lori Sussel
MGI ID:	MGI:5485212
Synonyms:	Ghrl-LCA
Gene:	Ghrl  Location: Chr6:113693080-113696841 bp, - strand  Genetic Position: Chr6, 52.84 cM, cytoband E3

Germline Transmission:	Unknown
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, RMCE-ready) Mutations:    Insertion, Intragenic deletion   Mutation details: Positive and negative selection cassettes flanked by modified lox sites were inserted into the Grhl locus by homologous recombination, replacing the region from 2678 bp upstream of exon 1 to 473 bp downstream of exon 5. This creates a locus cassette acceptor (LCA) allele which can be used for recombinase mediated cassette exchange (RMCE) to generate various knock-in alleles. (J:195663)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghrl Mutation:	7 strains or lines available

Original:	J:195663 Arnes L, et al., Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One. 2012;7(12):e52026
All:	1 reference(s)