b2b1876Clo Chemically induced Allele Detail MGI Mouse (MGI:5476172)

b2b1876Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b1876Clo
Name:	Mutant line 1876; Bench to Bassinet Program (B2B/CVDC), mutation 1876 Cecilia Lo
MGI ID:	MGI:5476172
Synonyms:	Boombox
Gene:	b2b1876Clo Location: unknown
Alliance:	b2b1876Clo page

Mutant 1876-002-1 (E14.5) exhibits parallel outflow tracts which is confirmed by EFIC imaging to be DORV

Show the 9 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1876Clo, and may be present in stocks carrying this mutation.

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b1876Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Cardiac phenotype: Double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), ventricular noncompaction

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1100	Atrioventricular canal (endocardial cushion defect)
1802	Excessive myocardial trabeculation or noncompaction

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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