Tg(Myh6*-mCherry)2Mik
Transgene Detail
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| Symbol: |
Tg(Myh6*-mCherry)2Mik |
| Name: |
transgene insertion 2, Michael I Kotlikoff |
| MGI ID: |
MGI:5475556 |
| Synonyms: |
alpha-MHC-mCherry, alphaMHC-mCherry, a-MHC-mCherry, aMHC-mCherry, cardiac mCherry |
| Transgene: |
Tg(Myh6*-mCherry)2Mik Location: unknown
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| Alliance: |
Tg(Myh6*-mCherry)2Mik page
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| Strain of Origin: |
(C57BL/6J x DBA/2NCrl)F2
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: The alpha-MHC-mCherry transgene contains a cardiac-specific alpha myosin heavy-chain (Myh6) mouse
promoter sequence upstream of an mCherry fluorescent protein cDNA sequence. The modified mouse Myh6 promoter sequence is minimally active/attenuated through the ablation of three GATA sites and two
thyroid-like response elements, thereby directing cardiac-specific mCherry expression and decreased background expression. Founder line 2 were found to have extremely bright mCherry fluorescence in the heart at all stages of development.
(J:188625)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:188625 Jesty SA, et al., c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13380-5 |
| All: |
11 reference(s) |
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Analysis Tools
