Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Myh6*-mCherry)2Mik
Name:	transgene insertion 2, Michael I Kotlikoff
MGI ID:	MGI:5475556
Synonyms:	alpha-MHC-mCherry, alphaMHC-mCherry, a-MHC-mCherry, aMHC-mCherry, cardiac mCherry
Transgene:	Tg(Myh6*-mCherry)2Mik  Location: unknown
Alliance:	Tg(Myh6*-mCherry)2Mik page

Strain of Origin:

(C57BL/6J x DBA/2NCrl)F2

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Mutation details: The alpha-MHC-mCherry transgene contains a cardiac-specific alpha myosin heavy-chain (Myh6) mouse promoter sequence upstream of an mCherry fluorescent protein cDNA sequence. The modified mouse Myh6 promoter sequence is minimally active/attenuated through the ablation of three GATA sites and two thyroid-like response elements, thereby directing cardiac-specific mCherry expression and decreased background expression. Founder line 2 were found to have extremely bright mCherry fluorescence in the heart at all stages of development. (J:188625)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:188625 Jesty SA, et al., c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13380-5
All:	8 reference(s)