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Gene Expression Data
Assay Details
Assay
Reference: J:81317 Yamashiro T, et al., Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev. 2002 Dec;119 Suppl 1:S107-10
Assay type: RNA in situ
MGI Accession ID: MGI:5475170
Gene symbol: Runx1
Gene name: runt related transcription factor 1
Probe: Runx1 cDNA4
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1A: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: frontal bone primordium Present Regionally restricted 1A Expression was detected in osteogenic regions.
TS21: mandible Present Regionally restricted 1A Expression was detected in osteogenic regions.
TS21: maxilla Present Regionally restricted 1A Expression was detected in osteogenic regions.
TS21: Meckel's cartilage Present 1A
TS21: eyelid mesenchyme Present 1A
TS21: nasal septum Present 1A
TS21: sphenoid bone pre-cartilage condensation Present Regionally restricted 1A Expression was detected in the ala orbitalis.
TS21: olfactory epithelium Present 1A
TS21: palatal shelf epithelium Present 1A

Specimen 2A: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present Regionally restricted 2A Expression was detected in dental epithelium on the buccal side.

Specimen 2D: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: lower jaw mesenchyme Present Regionally restricted 2D Expression was detected in the mesenchyme that extends from the perichondrium of Meckel's cartilage, but not in the mesenchyme expanded from ossified mandibular bone.
TS21: lower jaw tooth epithelium Present Regionally restricted 2D Expression was detected in dental epithelium on the buccal side.

Specimen 2D': embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: upper jaw molar epithelium Present Regionally restricted 2D inset Expression was detected in the buccal aspect of the dental epithelium.

Specimen 2G: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: lower jaw tooth epithelium Present Regionally restricted 2G Expression was detected in the buccal aspect of the dental epithelium.
TS22: lower jaw mesenchyme Present Regionally restricted 2G Expression was detected in the mesenchyme that extends from the perichondrium of Meckel's cartilage, but not in the mesenchyme expanded from ossified mandibular bone.

Specimen 2G': embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: upper jaw molar epithelium Present Regionally restricted 2G inset Expression was detected in the buccal aspect of the dental epithelium.

Specimen 2J: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: lower jaw tooth epithelium Present Regionally restricted 2J Expression was detected in dental epithelium on the buccal and lingual side.

Specimen 2J': embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: upper jaw molar epithelium Present Regionally restricted 2J inset Expression was detected in the buccal and lingual aspect of the dental epithelium.

Specimen 2M: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: lower jaw tooth enamel organ Weak Regionally restricted 2M Weak expression was detected in the outer enamel epithelium.

Specimen 2P: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: enamel organ Weak Regionally restricted 2P Weak expression was detected in the outer enamel epithelium.
TS27: lower jaw molar Present Regionally restricted 2P Some localized expression was detected in ameloblasts.

Specimen 3A: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: lower jaw incisor Present 3A
TS27: lower jaw molar Present 3A

Specimen 3B: postnatal day 2; Runx3tm1Yg/Runx3tm1Yg (more )
Structure Level Pattern Image Note
TS27: lower jaw incisor Present 3B Expression patterns were similar in mutant and wild type mice.
TS27: lower jaw molar Present 3B Expression patterns were similar in mutant and wild type mice.

Specimen 4A: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: palatal shelf epithelium Weak 4A

Specimen 4B: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Moderate Regionally restricted 4B Expression was detected in the palatal shelf epithelium contacting the tongue.

Specimen 4C: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Present Regionally restricted 4C Prior to horizontalization of the shelves, the expression was more intense and localized to the tips of the shelves.

Specimen 4D: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: palate epithelium Present Regionally restricted 4D After the fusion of the shelves, expression was detected at the fusion site.
TS24: palate mesenchyme Present Regionally restricted 4D After the fusion of the shelves, expression was detected at the fusion site.
TS24: nasal cavity epithelium Present Regionally restricted 4D Expression was detected at the site of palatal shelf fusion.
TS24: oral epithelium Present Regionally restricted 4D Expression was detected at the site of palatal shelf fusion.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory