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Gene Expression Data
Assay Details
Assay
Reference: J:171432 Fernandez-Valdivia R, et al., Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011 May;138(10):1925-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5473561
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: Anti-Pecam1
Results
Specimen 4A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4A
Specimen 4B: embryonic day 8.5; Poglut1Gt(IST10323G11)Tigm/Poglut1+ (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4B
Specimen 4C: embryonic day 8.5; Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4C Staining indicated severe cardiovascular defects - abnormal vascularization, absence of dorsal aorta and intersomitic vasculature, and cardia bifida.
Specimen 4D: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4D
Specimen 4E: embryonic day 8.5; Poglut1Gt(IST10323G11)Tigm/Poglut1+ (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4E
Specimen 4F: embryonic day 8.5; Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm (more )
Structure Level Pattern Image Note
TS13: cardiovascular system Present 4F Staining indicated severe cardiovascular defects - abnormal vascularization, absence of dorsal aorta and intersomitic vasculature, and cardia bifida. No staining was detected on the dorsal side of the head structures.
Specimen 4G: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: cardiovascular system Present 4G
Specimen 4H: embryonic day 9.5; Poglut1Gt(IST10323G11)Tigm/Poglut1+ (more )
Structure Level Pattern Image Note
TS15: cardiovascular system Present 4H
Specimen 4I: embryonic day 9.5; Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm (more )
Structure Level Pattern Image Note
TS15: cardiovascular system Present Regionally restricted 4I Disorganized vascular networks were noted on the dorsal side of the head in some embryos. Other abnormalities noted included the absence of the heart and unfused cardiogenic plates.
Specimen 4J: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Regionally restricted 4J Expression was detected in yolk sac vasculature.
Specimen 4K: embryonic day 8.75; Poglut1Gt(IST10323G11)Tigm/Poglut1+ (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Regionally restricted 4K Expression was detected in yolk sac vasculature.
Specimen 4L: embryonic day 8.75; Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Regionally restricted 4L Staining indicated severe vascular remodeling defects in the yolk sac with large blood sinusoids.
Specimen 4M & 4P: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Regionally restricted 4P , 4M Expression was detected in the membrane of endothelial cells.
Specimen 4N & 4Q: embryonic day 8.75; Poglut1Gt(IST10323G11)Tigm/Poglut1+ (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Regionally restricted 4N , 4Q Expression was detected in the membrane of endothelial cells.
Specimen 4O & 4R: embryonic day 8.75; Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm (more )
Structure Level Pattern Image Note
TS14: yolk sac Present Diffuse 4R , 4O There was a lack of endothelial remodeling in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory