Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gad2tm1.1(cre/ERT2)Gmbk
Name:	glutamic acid decarboxylase 2; targeted mutation 1.1, Gero Miesenboeck
MGI ID:	MGI:5473402
Synonyms:	Gad2::Cre-ERT2
Gene:	Gad2  Location: Chr2:22512262-22583889 bp, + strand  Genetic Position: Chr2, 15.15 cM, cytoband A-B
Alliance:	Gad2tm1.1(cre/ERT2)Gmbk page

Germline Transmission:	Earliest citation of germline transmission: J:194305
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gad2tm1.1(cre/ERT2)Gmbk expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gad2 (MGI:95634)   Mutation details: A cassette encoding IRES-cre/ERT2 fused to an Frt-flanked neo resistance marker was inserted into the 3' untranslated region of the Gad2 gene immediately following the stop codon. The neo marker was excised excised by breeding founder animals ot Flp-expressing mice. (J:194305)

Activity:	Tissue activity of this recombinase allele
Driver:	Gad2 (mouse) Summary of all recombinase alleles driven by Gad2. Alliance mouse Gad2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gad2 Mutation:	60 strains or lines available

Original:	J:194305 Katzel D, et al., The columnar and laminar organization of inhibitory connections to neocortical excitatory cells. Nat Neurosci. 2011 Jan;14(1):100-7
All:	9 reference(s)