Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Casp4del
Name:	caspase 4, apoptosis-related cysteine peptidase; deletion
MGI ID:	MGI:5473345
Synonyms:	Casp129
Gene:	Casp4  Location: Chr9:5308828-5336783 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Alliance:	Casp4del page

Strain of Origin:

129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ

Allele Type:    Spontaneous (Null/knockout) Mutation:    Intragenic deletion   Mutation details: RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and 8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage. (J:193522)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Casp4 Mutation:	30 strains or lines available

Original:	J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
All:	63 reference(s)