Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dll1tm1.1(cre/ERT2)Cle
Name:	delta like canonical Notch ligand 1; targeted mutation 1.1, Hans Clevers
MGI ID:	MGI:5473277
Synonyms:	Dll1GFP-Creert2, Dll1GFP-ires-CreERT2
Gene:	Dll1  Location: Chr17:15587616-15597134 bp, - strand  Genetic Position: Chr17, 8.95 cM
Alliance:	Dll1tm1.1(cre/ERT2)Cle page

Germline Transmission:	Earliest citation of germline transmission: J:193937
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Dll1tm1.1(cre/ERT2)Cle expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dll1 (MGI:104659)   Mutation details: Homologous recombination was employed to insert an EGFP-IRES-cre/ERT2 cassette, Frt-flanked neo selection cassette and polyA signal into the ATG codon of exon 1 of Dll1 in ES cells. The neo marker was deleted in vivo by flippase (Flp) expression. GFP expression can be detected by confocal analysis in some mesenchymal cells and blood vessels, and in intestinal epithelial cells at the bottom and higher up in crypts. (J:193937)

Activity:	Tissue activity of this recombinase allele
Driver:	Dll1 (mouse) Summary of all recombinase alleles driven by Dll1. Alliance mouse Dll1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll1 Mutation:	46 strains or lines available

Original:	J:193937 van Es JH, et al., Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol. 2012 Oct;14(10):1099-104
All:	4 reference(s)