Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syngap1tm1.1Geno
Name:	synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1.1, Genoway
MGI ID:	MGI:5469865
Synonyms:	SYNGAP1fl
Gene:	Syngap1  Location: Chr17:27160227-27191408 bp, + strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Syngap1tm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:193208
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted usptream of exon 6. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 6 and 7 floxed. (J:193208)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

8 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syngap1 Mutation:	49 strains or lines available

Original:	J:193208 Clement JP, et al., Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23
All:	5 reference(s)