Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-CTNNB1)Tcd
Name:	collagen, type I, alpha 1; targeted mutation 1, TC Dale
MGI ID:	MGI:5469323
Synonyms:	Tet-OdeltaN89beta-catenin
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-CTNNB1)Tcd page

Germline Transmission:	Earliest citation of germline transmission: J:193365
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-CTNNB1)Tcd expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human CTNNB1 (1499) Ctnnb1  (MGI:88276)   Col1a1tm1(tetO-CTNNB1)Tcd expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note Not Specified tetO   Mutation details: RCME on KH2 cells inserted a cassette that contains the tetracycline response element driving inducible expression of the truncated human cDNA (deltaN89) with MYC tag into the 3'UTR. (J:193365)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:193365 Jarde T, et al., In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system. Oncogene. 2013 Feb 14;32(7):883-93
All:	2 reference(s)