Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rbm4btm1Wtarn
Name:	RNA binding motif protein 4B; targeted mutation 1, Woan-Yuh Tarn
MGI ID:	MGI:5467988
Gene:	Rbm4b  Location: Chr19:4806480-4816199 bp, + strand  Genetic Position: Chr19, 4.11 cM
Alliance:	Rbm4btm1Wtarn page

Germline Transmission:	Earliest citation of germline transmission: J:192831
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing most of exon 2 was replaced with a promoterless DsRed-mammalian sterile 20 cassette and a floxed neo cassette via homologous recombination. RT-PCR confirmed the absence of mRNA expression in homozygous MEFs and detected an increase in expression of Rbm4 . (J:192831)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbm4b Mutation:	16 strains or lines available

Original:	J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All:	3 reference(s)