Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cx3cr1tm2.1(cre/ERT2)Jung
Name:	C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Steffen Jung
MGI ID:	MGI:5467985
Synonyms:	Cx3cr1creER
Gene:	Cx3cr1  Location: Chr9:119877749-119897362 bp, - strand  Genetic Position: Chr9, 71.37 cM
Alliance:	Cx3cr1tm2.1(cre/ERT2)Jung page

Germline Transmission:	Earliest citation of germline transmission: J:193038
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Cx3cr1tm2.1(cre/ERT2)Jung expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cx3cr1 (MGI:1333815)   Mutation details: A cre/ERT2 cassette with a floxed neo gene was inserted by RedE/T recombineering into a BAC containing the Cx3cr1 locus, replacing the coding exon of Cx3cr1. Properly targeted ES cells were aggregated with 8-cell embryos to generate chimeras. Chimeras were backcrossed to C57BL/6 mice. Tne neo was excised by crossing the animals to a cre deleter strain (Tg(Pgk1-cre)1Lni). (J:193038)

Activity:	Tissue activity of this recombinase allele
Driver:	Cx3cr1 (mouse) Summary of all recombinase alleles driven by Cx3cr1. Comparative matrix view of recombinase activities Alliance mouse Cx3cr1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cx3cr1 Mutation:	45 strains or lines available

Original:	J:193038 Yona S, et al., Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis. Immunity. 2013 Jan 24;38(1):79-91
All:	184 reference(s)