Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Mbd5tm1.2Gxu Name: methyl-CpG binding domain protein 5; targeted mutation 1.2, Guo-Liang Xu MGI ID: MGI:5466580 Gene: Mbd5  Location: Chr2:48839511-49209702 bp, + strand  Genetic Position: Chr2, 28.43 cM, cytoband C1 Alliance: Mbd5tm1.2Gxu page

Small body size of Mbd5tm1.2Gxu/Mbd5tm1.2Gxu mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:192212
Parent Cell Line:	MPI-II (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exon 1 and the neo cassette. RT-PCR confirmed the absence of protein expression in the brain, pancreas and liver. (J:192212)

Generation of the Mbd5tm1.1Gxu and Mbd5tm1.2Gxu alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbd5 Mutation:	68 strains or lines available

Original:	J:192212 Du Y, et al., The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012;7(10):e47358
All:	2 reference(s)