Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nubp1m1Nisw
Name:	nucleotide binding protein 1; mutation 1, Lee Niswander
MGI ID:	MGI:5463617
Synonyms:	line3-2
Gene:	Nubp1  Location: Chr16:10229812-10242292 bp, + strand  Genetic Position: Chr16, 5.61 cM
Alliance:	Nubp1m1Nisw page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Nucleotide substitutions   Mutation details: ENU induced two C to A transversions at position 743 and 803 resulting in a Threonine to Lysine and Proline to Glutamine amino acid change, respectively. Protein expression is detected in the distal lung epithelium; however the interaction with Nubp2 is disrupted in vitro. (J:191793) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nubp1 Mutation:	17 strains or lines available

Original:	J:191793 Schnatwinkel C, et al., Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871
All:	1 reference(s)