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b2b1801.2Clo
Chemically induced Allele Detail
Summary
Symbol: b2b1801.2Clo
Name: Mutant line 1801.2; Bench to Bassinet Program (B2B/CVDC), mutation 1801, subline 2 Cecilia Lo
MGI ID: MGI:5463581
Gene: b2b1801.2Clo  Location: unknown  
Alliance: b2b1801.2Clo page
Mutant 1801-004-LC shows a slightly stenotic transverse arch and the pulmonary artery is positioned further posterior which confirms the micro-CT finding of double outlet right ventricle (DORV)

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1801Clo.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1801.2Clo Mutation:  1 strain or line available
Notes
This mutation was derived from the parent line b2b1801Clo.

Summative Diagnosis:
Mutant Type 2:
Cardiovascular phenotype: Double outlet right ventricle (DORV)/overriding aorta (Ao), hypoplastic aortic arch, subaortic ventricular septal defect (VSD), and muscular ventricular septal defect (mVSD)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
1200 Coarctation
1300 Ventricular septal defect
1320 Ventricular septal defect, muscular
1432 Overriding aortic valve

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory