Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Pbsn-cre/Esr1*)14Abch
Name:	transgene insertion 14, Andreas Birbach
MGI ID:	MGI:5461708
Synonyms:	ProbasinBAC-MerCreMer
Transgene:	Tg(Pbsn-cre/Esr1*)14Abch  Location: unknown
Alliance:	Tg(Pbsn-cre/Esr1*)14Abch page

Strain of Origin:

C57BL/6NCrl

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Pbsn-cre/Esr1*)14Abch expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Pbsn (MGI:1860484)   Mutation details: A BAC (#RP23-456A6; containing the entire mouse probasin (Pbsn) gene) was modified to insert a MerCreMer sequence (a double fusion of the cre recombinase cDNA sequence flanked on each end with a mutated murine estrogen receptor (mer) ligand-binding domain, resulting in tamoxifen-inducible cre expression) driven by the Pbsn promoter/enhancer region. The construct was microinjected into fertilized C57BL/6NCrl oocytes. Founder line 14 was established by breeding the founder, carrying 8-11 copies of the transgene, to wild-type C57BL/6J mice. (J:154786)

Activity:	Tissue activity of this recombinase allele
Driver:	Pbsn (mouse) Summary of all recombinase alleles driven by Pbsn. Alliance mouse Pbsn gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:154786 Birbach A, et al., A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate. Genesis. 2009 Nov;47(11):757-64
All:	2 reference(s)