Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx18tm2.1(cre)Sev
Name:	T-box18; targeted mutation 2.1, Sylvia Evans
MGI ID:	MGI:5461544
Synonyms:	Tbx18Cre
Gene:	Tbx18  Location: Chr9:87584853-87613313 bp, - strand  Genetic Position: Chr9, 47.06 cM, cytoband E3.2
Alliance:	Tbx18tm2.1(cre)Sev page

Germline Transmission:	Earliest citation of germline transmission: J:191082
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Tbx18tm2.1(cre)Sev expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbx18 (MGI:1923615)   Mutation details: This is a modification of the Tbx18tm2(cre)Sev allele. Briefly, a cre sequence and FRT-flanked neo cassette were inserted into the Tbx18 gene upstream of the initiation codon to generate the initial allele, and the neo was subsequently removed by crossing the original mice to a FLP deleter strain. (J:137459, J:191082)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx18 (mouse) Summary of all recombinase alleles driven by Tbx18. Alliance mouse Tbx18 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx18 Mutation:	36 strains or lines available

Original:	J:191082 Clavel C, et al., Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell. 2012 Nov 13;23(5):981-94
All:	15 reference(s)