Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	S1pr1tm2.1Rlp
Name:	sphingosine-1-phosphate receptor 1; targeted mutation 2.1, Richard L Proia
MGI ID:	MGI:5461228
Synonyms:	S1pr1loxP
Gene:	S1pr1  Location: Chr3:115504082-115508704 bp, - strand  Genetic Position: Chr3, 50.0 cM
Alliance:	S1pr1tm2.1Rlp page

Germline Transmission:	Earliest citation of germline transmission: J:86450
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:86450)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:	30 strains or lines available

Original:	J:86450 Allende ML, et al., G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
All:	26 reference(s)