Gene Expression Data
Assay Details
Assay
|
Reference:
|
J:57066
Lovicu FJ, et al., Spatial and temporal expression of p57(KIP2) during murine lens development. Mech Dev. 1999 Aug;86(1-2):165-9
|
Assay type:
|
RNA in situ
|
MGI Accession ID:
|
MGI:5447577
|
Gene symbol:
|
Cdkn1c
|
Gene name:
|
cyclin dependent kinase inhibitor 1C
|
Probe:
|
Cdkn1c cDNA1
|
Probe preparation:
|
Antisense labelled with S35 RNA
|
Visualized with:
|
Autoradiography
|
|
Results
|
Specimen
not shown:
embryonic day 9.5
(more )
Specimen
not shown:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Level |
Pattern |
Image |
Note |
TS15: lens placode |
Ambiguous |
|
|
Authors report little to no expression in lens placode or other surrounding tissues.
|
Specimen
1C:
embryonic day 10.5
(more )
Specimen
1C:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Specimen
2C:
embryonic day 11.0
(more )
Specimen
2C:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 11.0
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Level |
Pattern |
Image |
Note |
TS18: lens vesicle |
Present |
Regionally restricted |
2C
|
Expression upregulated in the posterior cells of the lens vesicle (presumptive primary fibres).
|
Specimen
3D:
embryonic day 11.5
(more )
Specimen
3D:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Specimen
4D:
embryonic day 13.5
(more )
Specimen
4D:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 13.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Level |
Pattern |
Image |
Note |
TS21: lens fiber |
Present |
Regionally restricted |
4D
|
Strongest expression at the lens cortex associated with new fibre formation; lower expression in the central mass of primary lens fibre cells.
|
Specimen
5D:
embryonic day 14.5
(more )
Specimen
5D:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Level |
Pattern |
Image |
Note |
TS22: lens anterior epithelium |
Present |
Regionally restricted |
5D
|
Stronger expression in the anterior lens epithelium in comparison with the peripheral epithelium.
|
TS22: posterior lens fiber |
Strong |
Regionally restricted |
5D
|
Strongest expression in epithelial cells posterior to the lens equator, restricted to newly differentiating secondary fibres.
|
TS22: eye |
Present |
Regionally restricted |
5D
|
Expression in the peripheral optic cup (presumptive ciliary body and iris).
|
TS22: hyaloid vascular plexus |
Present |
|
5D
|
|
Specimen
6A:
postnatal day 7
(more )
Specimen
6A:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
postnatal day 7
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: lens equatorial epithelium |
Present |
Regionally restricted |
6A
|
Expression restricted to a narrow band of cells within the transitional zone where cells are undergoing early stages of secondary fibre differentiation.
|
TS28: lens fiber |
Absent |
|
6A
|
No expression in the fibre mass undergoing fibre maturation.
|
Specimen
6B:
postnatal day 21
(more )
Specimen
6B:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
postnatal day 21
|
Sex:
|
Not Specified
|
Type:
|
section
|
|