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Gene Expression Data
Assay Details
Assay
Reference: J:57066 Lovicu FJ, et al., Spatial and temporal expression of p57(KIP2) during murine lens development. Mech Dev. 1999 Aug;86(1-2):165-9
Assay type: RNA in situ
MGI Accession ID: MGI:5447577
Gene symbol: Cdkn1c
Gene name: cyclin dependent kinase inhibitor 1C
Probe: Cdkn1c cDNA1
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: lens placode Ambiguous Authors report little to no expression in lens placode or other surrounding tissues.

Specimen 1C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: eye Present Regionally restricted 1C Earliest expression in the lens pit and adjacent ocular tissues.
TS17: lens pit Present Regionally restricted 1C Higher levels of expression in the posterior lens pit,
TS17: optic cup inner layer Present 1C
TS17: optic cup outer layer Present 1C

Specimen 2C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: lens vesicle Present Regionally restricted 2C Expression upregulated in the posterior cells of the lens vesicle (presumptive primary fibres).

Specimen 3D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lens vesicle posterior epithelium Strong 3D
TS19: lens vesicle anterior epithelium Weak 3D

Specimen 4D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lens fiber Present Regionally restricted 4D Strongest expression at the lens cortex associated with new fibre formation; lower expression in the central mass of primary lens fibre cells.

Specimen 5D: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lens anterior epithelium Present Regionally restricted 5D Stronger expression in the anterior lens epithelium in comparison with the peripheral epithelium.
TS22: posterior lens fiber Strong Regionally restricted 5D Strongest expression in epithelial cells posterior to the lens equator, restricted to newly differentiating secondary fibres.
TS22: eye Present Regionally restricted 5D Expression in the peripheral optic cup (presumptive ciliary body and iris).
TS22: hyaloid vascular plexus Present 5D

Specimen 6A: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: lens equatorial epithelium Present Regionally restricted 6A Expression restricted to a narrow band of cells within the transitional zone where cells are undergoing early stages of secondary fibre differentiation.
TS28: lens fiber Absent 6A No expression in the fibre mass undergoing fibre maturation.

Specimen 6B: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Present Regionally restricted 6B Size of expression domain is reduced compared with earlier stage. Expression in anterior lens epithelium.
TS28: ciliary body Weak 6B
TS28: iris Weak 6B


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory