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Gene Expression Data
Assay Details
Assay
Reference: J:87375 Esni F, et al., Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev. 2004 Jan;121(1):15-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5444113
Gene symbol: Nes
Gene name: nestin
Antibody: anti-nestin
Detection system: Cy5
Results
Specimen 1B,C,D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Regionally restricted 1B , 1C , 1D Strong expression in pancreatic mesenchymal cells. Lower level of expression in undifferentiated epithelial cells in the embryonic pancreas. No expression in differentiated alpha-cells.
TS18: foregut epithelium Absent 1B , 1D , 1C No expresssion in adjacent foregut endoderm.
Specimen 1F,G,H: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 1F , 1H , 1G Expression in pancreatic mesenchymal cells. Authors state that epithelial expression is lost, concomitant with differentiation of endocrine and exocrine cell types.
Specimen 1J,K,L: postnatal adult (more )
Structure Level Pattern Image Note
TS28: pancreatic acinus Present Regionally restricted 1L , 1K , 1J No expression in epithelial cells. Expression only in endothelial and mesenchymal peri-acinar cells.
Specimen 2B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Regionally restricted 2B Expression in undifferentiated pancreatic epithelial cells, but not in differentiated cells.
TS18: foregut epithelium Absent 2B
Specimen 2C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Regionally restricted 2C Expression in undifferentiated cells. Expression in undifferentiated cells.
TS18: foregut epithelium Absent 2C No expression in adjacent gut epithelium.
Specimen 2C': embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: foregut mesenchyme Present Regionally restricted 2C' At the level of foregut, expression in mesenchymal cells flanking the gut epithelium.
Specimen 2C": embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Regionally restricted 2C" At the level of the pancreatic bud, expression in pancreatic epithelial cells.
Specimen 2H: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Regionally restricted 2H No expression in differentiated endocrine cells.
Specimen 2I,I': embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: pancreas primordium dorsal bud Present Scattered 2I/I' No expression in differentiated endocrine cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory