Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vangl1tm1.1Nat
Name:	VANGL planar cell polarity 1; targeted mutation 1.1, Jeremy Nathans
MGI ID:	MGI:5440498
Synonyms:	Vangl1CKO
Gene:	Vangl1  Location: Chr3:102060899-102112009 bp, - strand  Genetic Position: Chr3, 44.3 cM
Alliance:	Vangl1tm1.1Nat page

Germline Transmission:	Earliest citation of germline transmission: J:228792
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted at an SpeI site 384 bp 3' of the third coding exon, in intron 3. A second loxP together with a Frt-PGK-neo-Frt selection cassette site was inserted at a StuI site 279 bp 5' of the exon, in intron 2. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:228792)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

7 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vangl1 Mutation:	85 strains or lines available

Original:	J:228792 Chang H, et al., The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Dev Biol. 2016 Jan 1;409(1):181-93
All:	7 reference(s)