Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Kpna1tm1.1Yyo
Name:	karyopherin subunit alpha 1; targeted mutation 1.1, Yoshihiro Yoneda
MGI ID:	MGI:5439492
Synonyms:	Impalpha5flox
Gene:	Kpna1  Location: Chr16:35803693-35859479 bp, + strand  Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
Alliance:	Kpna1tm1.1Yyo page

Germline Transmission:	Earliest citation of germline transmission: J:188099
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:188099)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kpna1 Mutation:	67 strains or lines available

Original:	J:188099 Moriyama T, et al., Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery. FEBS J. 2011 May;278(9):1561-72
All:	1 reference(s)