Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Alpl-cre/ERT2)12Gcos
Name:	transgene insertion 12, Giulio Cossu
MGI ID:	MGI:5439469
Synonyms:	Tg:TN-AP-CreERT2
Transgene:	Tg(Alpl-cre/ERT2)12Gcos  Location: unknown
Alliance:	Tg(Alpl-cre/ERT2)12Gcos page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Alpl-cre/ERT2)12Gcos expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Alpl (MGI:87983)   Mutation details: Homologous recombination in bacterial cells inserted a construct with cre recombinase fused with the tamoxifen-responsive mutated estrogen receptor sequence, ERT2, into the ATG uptstream starting coding region of the tissue-nonspecific alkaline phosphatase gene (Alpl) in BAC clone RP23-400F8. The correctly targeted BAC was electroporated into fertilized eggs, producing seven founders. These were crossed to R26R reporter mice and three lines (3, 6, and 12) showed efficient cre recombination in progeny. Most subsequent experiments were performed with the line propagated from founder 12 which was more fertile than the other founders. (J:188175)

Activity:	Tissue activity of this recombinase allele
Driver:	Alpl (mouse) Summary of all recombinase alleles driven by Alpl. Alliance mouse Alpl gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:188175 Dellavalle A, et al., Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nat Commun. 2011;2:499
All:	6 reference(s)