Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Eno2-cre/Esr1*)778Vchl
Name:	transgene insertion 778, Vincent Chi Hang Lui
MGI ID:	MGI:5438647
Synonyms:	NSE-MerCreMer
Transgene:	Tg(Eno2-cre/Esr1*)778Vchl  Location: unknown
Alliance:	Tg(Eno2-cre/Esr1*)778Vchl page

Strain of Origin:

(CBA x 129)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Eno2-cre/Esr1*)778Vchl expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Eno2 (24334) Eno2  (MGI:95394)   Mutation details: The sequence of the rat NSE (neural specific enolase; Eno2) was inserted 5' upstream of cDNA encoding cre recombinase flanked by mutated mouse estrogen receptor ligand-binding domains (MerCreMer). The construct was injected into fertilized oocytes and 6 founders (4 male, 2 female) were generated and 2 (#'s 778 and 805) were found to show expression in the brain and intestine in F3 animals by RT-PCR or Western blot. The other 2 lines did not show protein expression in the brain or intestine despite MerCreMer transcript expression determined by RT-PCR. Transcript expression in line 778 was detected at E14.5, corresponding to neurogenesis in the CNS and ENS. Both lines were further characterized by analyses of tissue from offspring of crosses to reporter mice. Line 778 was created as a representative line. (J:187253)

Generation of Tg(Eno2-cre/Esr1*)778Vchl.

Activity:	Tissue activity of this recombinase allele
Driver:	Eno2 (rat) Summary of all recombinase alleles driven by Eno2. Alliance rat Eno2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:187253 Kam MK, et al., Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons. PLoS One. 2012;7(5):e35799
All:	1 reference(s)