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Gene Expression Data
Assay Details
Assay
Reference: J:83659 Wright TJ, et al., Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003 Aug;130(15):3379-90
Assay type: RNA in situ
MGI Accession ID: MGI:5435915
Gene symbol: Dlx5
Gene name: distal-less homeobox 5
Probe: Dlx-5 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3I: embryonic day 9.5; Fgf3tm1Mrc/Fgf3+, Fgf10tm1Wss/Fgf10+ (more )
Structure Level Pattern Image Note
TS15: otocyst Present 3I
TS15: forelimb bud Present 3I
TS15: 1st branchial arch Present 3I
TS15: 2nd branchial arch Present 3I
TS15: future forebrain Present 3I
Specimen 3J: embryonic day 9.5; Fgf3tm1Mrc/Fgf3+, Fgf10tm1Wss/Fgf10+ (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 3J Expression is present in the dorsolateral wall.
Specimen 3K: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10tm1Wss (more )
Structure Level Pattern Image Note
TS15: otocyst Absent 3K Expression was lacking in the otic region, even when the double mutants appeared to have microvesicles.
TS15: forelimb bud Absent 3K
TS15: 1st branchial arch Present 3K
TS15: 2nd branchial arch Present 3K
TS15: future forebrain Present 3K
Specimen 3L: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10tm1Wss (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Absent 3L Expression was lacking in the otic region, even when the double mutants appeared to have microvesicles.
Specimen 4I: embryonic day 8.5 (more )
Note: Ten somite-stage embryo.
Structure Level Pattern Image Note
TS13: otic placode Present 4I
TS13: future prosencephalon Present 4I Expression is present in the forebrain.
Specimen 4J: embryonic day 8.5 (more )
Note: Ten somite-stage embryo. This section is through the otic region.
Structure Level Pattern Image Note
TS13: otic placode Present 4J
TS13: future prosencephalon Present 4J Expression is present in the forebrain.
Specimen 4K: embryonic day 8.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10tm1Wss (more )
Note: Ten somite-stage embryo.
Structure Level Pattern Image Note
TS13: embryo ectoderm Present Regionally restricted 4K Expression is found in a region located more ventrally than that seen in the control.
TS13: future prosencephalon Present 4K Expression is present in the forebrain.
Specimen 4L: embryonic day 8.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10tm1Wss (more )
Note: Ten somite-stage embryo. This section is through the otic region.
Structure Level Pattern Image Note
TS13: embryo ectoderm Present Regionally restricted 4L Expression is found in a region located more ventrally than that seen in the control. It is excluded from the dorsal surface ectoderm (which is unusually thin).
TS13: future prosencephalon Present 4L Expression is present in the forebrain.
Specimen 6I: embryonic day 9.5; Fgf10tm1Wss/Fgf10tm1Wss (more )
Structure Level Pattern Image Note
TS15: otocyst Present 6I
TS15: branchial arch Present 6I
TS15: forelimb bud Present 6I
TS15: future forebrain Present 6I
Specimen 6J: embryonic day 9.5; Fgf10tm1Wss/Fgf10tm1Wss (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 6J Expression is present in the dorsolateral wall.
Specimen 6K: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc (more )
Structure Level Pattern Image Note
TS15: otocyst Present 6K The size and the location of the otic vesicles are variably altered in the mutants.
TS15: branchial arch Present 6K
TS15: forelimb bud Present 6K
TS15: future forebrain Present 6K
Specimen 6L: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 6L In mutants expression is expanded toward ventral and medial regions. In addition, the size and the location of the otic vesicles are variably altered in the mutants.
Specimen 6M: embryonic day 9.5; Fgf3tm1Mrc/Fgf3+, Fgf10tm1Wss/Fgf10tm1Wss (more )
Structure Level Pattern Image Note
TS15: otocyst Present 6M
TS15: branchial arch Present 6M
TS15: forelimb bud Present 6M
TS15: future forebrain Present 6M
Specimen 6N: embryonic day 9.5; Fgf3tm1Mrc/Fgf3+, Fgf10tm1Wss/Fgf10tm1Wss (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 6N Expression is present in the dorsolateral wall. According to one measurement, otic vesicles in the mutants are only 72% of the size of those in controls and the level of expression is reduced.
Specimen 6O: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10+ (more )
Structure Level Pattern Image Note
TS15: otocyst Present 6O
TS15: branchial arch Present 6O
TS15: forelimb bud Present 6O
TS15: future forebrain Present 6O
Specimen 6P: embryonic day 9.5; Fgf3tm1Mrc/Fgf3tm1Mrc, Fgf10tm1Wss/Fgf10+ (more )
Note: This section is through the otic region.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 6P Expression is present in the dorsolateral wall. According to one measurement, otic vesicles in the mutants are only 47% of the size of those in controls and the level of expression is reduced.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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