Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Kcnn3tm2.1Jpad
Name:	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; targeted mutation 2.1, John P Adelman
MGI ID:	MGI:5435580
Synonyms:	SK3flox
Gene:	Kcnn3  Location: Chr3:89427471-89579801 bp, + strand  Genetic Position: Chr3, 39.16 cM, cytoband F2
Alliance:	Kcnn3tm2.1Jpad page

Germline Transmission:	Earliest citation of germline transmission: J:187145
Parent Cell Line:	Duffy (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site upstream of the translation initiation codon in exon 1. A frt-flanked neomycin resistance (neo) cassette and a second loxP site were inserted downstream of exon 1. Heterozygous mice were bred with Flp transgenic mice to delete the neo cassette. (J:187145)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnn3 Mutation:	51 strains or lines available

Original:	J:187145 Deignan J, et al., SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. 2012 Aug 16;217:67-76
All:	5 reference(s)