Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Col11a2-cre)4Nhzi
Name:	transgene insertion 4, Nobumichi Hozumi
MGI ID:	MGI:5435262
Synonyms:	alpha2(XI) collagen-Cre line #4
Transgene:	Tg(Col11a2-cre)4Nhzi  Location: unknown
Alliance:	Tg(Col11a2-cre)4Nhzi page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Col11a2-cre)4Nhzi expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Col11a2   Mutation details: Cre recombinase replaced the beta-galactosidase gene in a construct containing the -742bp Col11a2 promoter sequence, SV40 RNA splice site, lacZ sequence, and Col11a2 first intron. The 4.2 kb construct was microinjected into fertilized pronuclei. 5 founders were obtained. 2 lines (1 and 5) did show recombination in crosses to lacZ reporter mice. Line 2 showed cre activity in neural tissue and line 3 had ubiquitous activity. Line 4 was chosen due to its restricted cre activity pattern, although it had a low transgene copy number compared to the other lines. (J:187063)

Activity:	Tissue activity of this recombinase allele
Driver:	Col11a2 (species not specified) Summary of all recombinase alleles driven by Col11a2. Comparative matrix view of recombinase activities

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:187063 Fujimaki R, et al., Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse alpha2(XI) collagen promoter. J Bone Miner Metab. 2005;23(3):270-3
All:	1 reference(s)