Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Col11a2-cre)2Ntsu
Name:	transgene insertion 2, Noriyuki Tsumaki
MGI ID:	MGI:5435242
Synonyms:	11Prom-Cre, Col11a2prom-Cre
Transgene:	Tg(Col11a2-cre)2Ntsu  Location: unknown
Alliance:	Tg(Col11a2-cre)2Ntsu page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Col11a2-cre)2Ntsu expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Col11a2   Mutation details: The cre sequence replaced the beta-galactosidase gene in a plasmid containing the Col11a2 promoter (-742 to +380bp). This construct was injected into fertilized ova to establish a transgenic line. Animals were crossed to reporter mice and at E14.5, cre activity was observed only in flat chondrocytes, prehypertrophic and hypertrophic chondrocytes in limbs and ribs, but not in round choncrocytes at the ends of each primordial cartilage. Some aberrant activity was observed in the forebrain at E12.5. (J:142326)

Activity:	Tissue activity of this recombinase allele
Driver:	Col11a2 (species not specified) Summary of all recombinase alleles driven by Col11a2.

In Mice Carrying this Mutation:

56 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:142326 Iwai T, et al., Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem. 2008 Oct 3;283(40):27154-64
All:	3 reference(s)