Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sfrp2tm1.1Brle
Name:	secreted frizzled-related protein 2; targeted mutation 1.1, Brendan Lee
MGI ID:	MGI:5431901
Gene:	Sfrp2  Location: Chr3:83673628-83681621 bp, + strand  Genetic Position: Chr3, 37.37 cM
Alliance:	Sfrp2tm1.1Brle page

Germline Transmission:	Earliest citation of germline transmission: J:186306
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2 were replaced by a loxP-flanked TK-neomycin cassette. Cre-mediated recombination removed the neo cassette. Northern blot analysis confirmed the absence of transcript expression. (J:186306)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sfrp2 Mutation:	26 strains or lines available

Original:	J:186306 Morello R, et al., Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
All:	5 reference(s)