Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(CD207-cre/ERT2)1Dhka
Name:	transgene insertion 1, Daniel H Kaplan
MGI ID:	MGI:5431679
Synonyms:	huLangerin-CreERT2
Transgene:	Tg(CD207-cre/ERT2)1Dhka  Location: unknown
Alliance:	Tg(CD207-cre/ERT2)1Dhka page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(CD207-cre/ERT2)1Dhka expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human CD207 (50489) Cd207  (MGI:2180021)   Mutation details: A cassette encoding an IRES-cre/ERT2 sequence was inserted in the 3' UTR of the human langerin (CD207) gene in the bacterial artificial chromosome (BAC) RP11-504O1 by homologous recombination. This generated a 61 kb fragment that was used to produce transgenic mice. (J:185586)

Activity:	Tissue activity of this recombinase allele
Driver:	CD207 (human) Summary of all recombinase alleles driven by CD207. Alliance human CD207 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:185586 Bobr A, et al., Autocrine/paracrine TGF-beta1 inhibits Langerhans cell migration. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10492-7
All:	5 reference(s)