Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Erv4-cre/ERT2*)657Slp
Name:	transgene insertion 657, Samuel L Pfaff
MGI ID:	MGI:5431581
Synonyms:	2C::ERT2-Cre-ERT2, Tg(MuERV-L-ERT2-Cre-ERT2)657Slp
Transgene:	Tg(Erv4-cre/ERT2*)657Slp  Location: unknown
Alliance:	Tg(Erv4-cre/ERT2*)657Slp page

Strain of Origin:

BALB/c and C57BL/6

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Erv4-cre/ERT2*)657Slp expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note virus Erv4   Mutation details: The 5' LTR of murine endogenous retrovirus with leucine tRNA primer (MuERV-L; MERVL; Erv4) and the primer binding site drive expression of tamoxifen-inducible Cre recombinase (2C::ERT2-Cre-ERT2). Two flanking ERT2 segments were inserted to make Cre activation less leaky. The transgenic vector was injected into CB6 (BALB/c and C57BL/6) embryos and the resultant strain was subsequently maintained on the same mixed genetic background by the donating laboratory. This is founder line 657. (J:186302)

Activity:	Tissue activity of this recombinase allele
Driver:	Erv4 (virus) Summary of all recombinase alleles driven by Erv4.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:186302 Macfarlan TS, et al., Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature. 2012 Jul 5;487(7405):57-63
All:	1 reference(s)