Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crisp4tm1(icre)Mpo
Name:	cysteine-rich secretory protein 4; targeted mutation 1, Matti Poutanen
MGI ID:	MGI:5431546
Synonyms:	Crisp4 KI
Gene:	Crisp4  Location: Chr1:18185415-18216126 bp, - strand  Genetic Position: Chr1, 5.65 cM, cytoband A4
Alliance:	Crisp4tm1(icre)Mpo page

Germline Transmission:	Earliest citation of germline transmission: J:185787
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Recombinase) Mutation:    Intragenic deletion   Crisp4tm1(icre)Mpo expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Crisp4 (MGI:1925331)   Mutation details: A construct containing a codon-improved cre (icre) recombinase-neomycin cassette was generated from a BAC containing the Crisp4 locus. The linearized vector targeted the third exon of Crisp4 in ES cells and homologys recombination resulted in a deletion causing a frameshift that disrupted endogenous gene expression. This allele expresses icre from the Crisp4 promoter, specifically in the epididymis. (J:185787)

Activity:	Tissue activity of this recombinase allele
Driver:	Crisp4 (mouse) Summary of all recombinase alleles driven by Crisp4. Alliance mouse Crisp4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crisp4 Mutation:	21 strains or lines available

Original:	J:185787 Turunen HT, et al., Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice. Biol Reprod. 2012 Jan;86(1):1-8
All:	1 reference(s)