b2b904Clo Chemically induced Allele Detail MGI Mouse (MGI:5431494)

b2b904Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b904Clo
Name:	Mutant line 904; Bench to Bassinet Program (B2B/CVDC), mutation 904 Cecilia Lo
MGI ID:	MGI:5431494
Synonyms:	Bright Eyes
Gene:	b2b904Clo Location: unknown
Alliance:	b2b904Clo page

Mutant 904-004-ND exhibits congested heart with congested and enlarged atria

Show the 11 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See b2b904.1Clo and b2b904.2Clo

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b904Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Mutant phenotype 1: Right ventricular myocardial noncompaction, dilated ventricular chamber
Mutant phenotype 2: Biventricular hypertrophy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1802	Excessive myocardial trabeculation or noncompaction
3608	Left ventricular hypertrophy
3609	Right ventricular hypertrophy
7505	Biventricular hypertrophy

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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