b2b576Clo Chemically induced Allele Detail MGI Mouse (MGI:5430052)

b2b576Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b576Clo
Name:	Mutant line 576; Bench to Bassinet Program (B2B/CVDC), mutation 576 Cecilia Lo
MGI ID:	MGI:5430052
Synonyms:	Rugby
Gene:	b2b576Clo Location: unknown
Alliance:	b2b576Clo page

Mutant 576-006-NA displays malpositioning of the great arteries, shown to be overriding aorta by EFIC histopathology

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b576Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Cardiac defects: Malalignment of the great arteries - double outlet right ventricle (DORV)/overriding Aorta (Ao).

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1432	Overriding aortic valve
0600	Double outlet right ventricle

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23