Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Frem1tm2.1Ksek
Name:	Fras1 related extracellular matrix protein 1; targeted mutation 2.1, Kiyotoshi Sekiguchi
MGI ID:	MGI:5427907
Synonyms:	QbrickRGE
Gene:	Frem1  Location: Chr4:82816164-82970576 bp, - strand  Genetic Position: Chr4, 39.4 cM
Alliance:	Frem1tm2.1Ksek page

Germline Transmission:	Earliest citation of germline transmission: J:185210
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette was inserted upstream of a modified exon 4 in which nucleotide substitution (T to A) results in the amino acid substitution of glutamic acid for aspartic acid at position 207 (D207E). Cre-mediated recombination removed the neo cassette. (J:185210)

Generation of the Frem1tm2.1Ksek allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Frem1 Mutation:	117 strains or lines available

Original:	J:185210 Kiyozumi D, et al., Basement membrane assembly of the integrin alpha8beta1 ligand nephronectin requires Fraser syndrome-associated proteins. J Cell Biol. 2012 May 28;197(5):677-89
All:	1 reference(s)