Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmc1tm1.1Ajg
Name:	transmembrane channel-like gene family 1; targeted mutation 1.1, Andrew J Griffith
MGI ID:	MGI:5427097
Synonyms:	Tmc1delta
Gene:	Tmc1  Location: Chr19:20760822-20931566 bp, - strand  Genetic Position: Chr19, 13.98 cM, cytoband B
Alliance:	Tmc1tm1.1Ajg page

Germline Transmission:	Earliest citation of germline transmission: J:184419
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 8 and 9 were replaced with an IRES-lacZ cassette and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. At P28 beta-galactosidase activity is detected in both type I and type II hair cells of the saccular macula, utricular macula, and cristae ampullaris. (J:184419)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmc1 Mutation:	60 strains or lines available

Original:	J:184419 Kawashima Y, et al., Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 2011 Dec;121(12):4796-809
All:	23 reference(s)