Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Il17rbtm1Tgi Name: interleukin 17 receptor B; targeted mutation 1, Masaru Taniguchi MGI ID: MGI:5426267 Synonyms: Il17rbtm1Hwata Gene: Il17rb  Location: Chr14:29718125-29730853 bp, - strand  Genetic Position: Chr14, 18.39 cM Alliance: Il17rbtm1Tgi page

Il17rbtm1Tgi/Il17rbtm1Tgi and Tcra-Jtm1Tgi/Tcra-Jtm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:184570
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette replaced the coding sequence in exon 1 and all of exon 2. Flow cytometry confirmed the absence of protein expression in the iNKT cells of the spleen. (J:184570)

Generation of the Il17rbtm1Tgi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il17rb Mutation:	41 strains or lines available

Original:	J:184570 Watarai H, et al., Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol. 2012 Feb;10(2):e1001255
All:	4 reference(s)