Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Egfrtm1.1Tyj
Name:	epidermal growth factor receptor; targeted mutation 1.1, Tyler Jacks
MGI ID:	MGI:5320891
Synonyms:	Egfrtm1.1(L858R)Tyj
Gene:	Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Alliance:	Egfrtm1.1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	V26.2 (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Humanized sequence) Mutations:    Insertion, Single point mutation   Mutation details: The targeting construct introduced an FRT site flanked neomycin resistance gene cassette into intron 20 and a T->G point mutation in exon 21, changing leucine codon 860 (CTG) to arginine (CGG) (p.L860R). The locus was re-targeted to place a lox-Stop-lox (LSL) cassette in intron 1. Flp-mediated recombination removed the neo cassette. The mutation is the equivalent of the human p.L858R mutation associated with lung cancer susceptibility. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:	85 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	3 reference(s)