Tg(CAG-EGFP,TGFB1*)C8Kul
Transgene Detail
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| Symbol: |
Tg(CAG-EGFP,TGFB1*)C8Kul |
| Name: |
transgene insertion C8, Ashok B Kulkarni |
| MGI ID: |
MGI:5319386 |
| Synonyms: |
beta1glo, Tg(CAG-EGFP,TGFB1*)C8Akul |
| Transgene: |
Tg(CAG-EGFP,TGFB1*)C8Kul Location: unknown
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| Alliance: |
Tg(CAG-EGFP,TGFB1*)C8Kul page
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| Transgene Type: |
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Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Tg(CAG-EGFP,TGFB1*)C8Kul expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| pig, domestic |
TGFB1 (397078) |
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Mutation details: The transgene was designed with (from 5' to 3') the CAG promoter (containing a CMV-IE enhancer/beta-actin promoter), a loxP-flanked enhanced green fluorescent protein (EGFP) and polyA signal, a hemagglutinin (HA)-tagged porcine transforming growth factor, beta 1 (Tgfb1) cDNA, and a 2x-polyA signal. The Tgfb1 cDNA was modified to be constitutively active by missense mutations of two cysteine residues (C223 and C225) to serines. Line C8 was generated.
(J:158613)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:158613 Hall BE, et al., Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest. 2010 Apr;90(4):543-55 |
| All: |
6 reference(s) |
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Analysis Tools
