Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CAG-EGFP,TGFB1*)C8Kul
Name:	transgene insertion C8, Ashok B Kulkarni
MGI ID:	MGI:5319386
Synonyms:	beta1glo, Tg(CAG-EGFP,TGFB1*)C8Akul
Transgene:	Tg(CAG-EGFP,TGFB1*)C8Kul  Location: unknown
Alliance:	Tg(CAG-EGFP,TGFB1*)C8Kul page

Strain of Origin:

FVB/NCrl

Transgene Type:    Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) Mutation:    Insertion   Tg(CAG-EGFP,TGFB1*)C8Kul expresses 1 gene Transgene expresses: Organism Expressed Gene Note pig, domestic TGFB1 (397078)   Mutation details: The transgene was designed with (from 5' to 3') the CAG promoter (containing a CMV-IE enhancer/beta-actin promoter), a loxP-flanked enhanced green fluorescent protein (EGFP) and polyA signal, a hemagglutinin (HA)-tagged porcine transforming growth factor, beta 1 (Tgfb1) cDNA, and a 2x-polyA signal. The Tgfb1 cDNA was modified to be constitutively active by missense mutations of two cysteine residues (C223 and C225) to serines. Line C8 was generated. (J:158613)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:158613 Hall BE, et al., Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest. 2010 Apr;90(4):543-55
All:	5 reference(s)