Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(LRRK2)66Mjff
Name:	transgene insertion 66, The Michael J Fox Foundation
MGI ID:	MGI:4834644
Transgene:	Tg(LRRK2)66Mjff  Location: Chr6:16279286-16327994 bp  Genetic Position: Chr6, Syntenic
Alliance:	Tg(LRRK2)66Mjff page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intergenic deletion   Tg(LRRK2)66Mjff expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human LRRK2 (120892) Lrrk2  (MGI:1913975)   Mutation details: Bacterial artificial chromosome (BAC) library was used to obtain a BAC containing the entire human hLRRK2 (leucine-rich repeat kinase 2) gene. This BAC also contained a frt-flanked neomycin selection (neo) cassette which was removed by induction of an arabinose Flp-recombinase. Lines 41, 66, 70, and 107 were created. Transgene insertion occurred on Chr 6, causing a 756 bp deletion. (J:177258)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:177258 Ouyang Y, Creation of a transgenic mouse expressing human LRRK2. MGI Direct Data Submission. 2011;
All:	3 reference(s)